Which clinical signs are associated with leptospirosis in infected animals?

Leptospirosis is a significant zoonotic disease caused by bacteria of the genus Leptospira, and it can manifest through various clinical signs in infected animals. The correct association of clinical signs with leptospirosis lies in the combination of fever, vomiting, and kidney failure.

Fever is a common systemic response to infection, indicating the body's immune response to the invading bacteria. Vomiting may occur as a gastrointestinal manifestation related to the hepatic and renal involvement characteristic of leptospirosis. Moreover, renal failure is critical in this disease, as Leptospira bacteria have a particular affinity for the kidneys, leading to interstitial nephritis and potentially severe kidney damage.

In contrast, other symptoms such as coughing and sneezing are typically associated with respiratory infections. Skin lesions and rashes may arise from other infectious agents but are not a hallmark of leptospirosis. Joint pain and lameness, while they can occur in some infections, do not reflect the primary clinical picture associated with leptospirosis. The combination of fever, vomiting, and kidney dysfunction is distinctive and highlights the pathogenicity and clinical implications of leptospirosis in affected animals.