Which clinical feature is most consistent with an abscess?

The feature that is most consistent with an abscess is localized swelling with pus. An abscess is a collection of pus that forms within the tissue as a result of infection. The pus is typically made up of dead tissue, bacteria, and white blood cells fighting the infection. This localized accumulation leads to significant swelling and tenderness in the affected area. The presence of pus is a hallmark sign, as it differentiates an abscess from other types of infections or inflammatory responses where pus may not be present.

While systemic fever, widespread erythema, and generalized lymphadenopathy can accompany an abscess due to the body's immune response, these symptoms are not specific to abscess formation. For instance, systemic fever can occur with various infections, and generalized lymphadenopathy often suggests a systemic infection rather than a localized process like an abscess. On the other hand, the localized nature of swelling and pus is a direct indication of an abscess, making it the most accurate and relevant choice in this context.